A mechanism for influenza subtype disappearance
Identifieur interne : 002838 ( Main/Exploration ); précédent : 002837; suivant : 002839A mechanism for influenza subtype disappearance
Auteurs : R. G. Whittaker [Australie] ; P. A. Underwood [Australie]Source :
- Medical Hypotheses [ 0306-9877 ] ; 1980.
English descriptors
- Teeft :
- Academic press, Amino acid changes, Antibody binding, Antigenic, Antigenic changes, Antigenic drift, Antigenic mutants, Antigenic site, Antigenic variation, Binding site, Blood cell, Blood cells, Cell binding, Conformational changes, Equilibrium filtration, Field strains, Growth characteristics, Haemagglutinin, Haemagglutinin genes, Haemagglutinin molecule, Haemagglutinin spike, Haemagglutinin spikes, Hong kong, Host cell binding site, Host cells, Human influenza, Influenza, Influenza haemagglutinin, Influenza subtypes, Influenza virus, Influenza viruses, Laver, Lowest estimate, Monoclonal antibodies, Mutant, Mutation, Negative binding, Negative binding mutants, Neuraminidase, Neuraminidase content, Neuraminidase spikes, Normalised results, Other hand, Population immunity, Recent experiments, Reciprocal titration, Simple mechanism, Spike, Subtype, Subtype change, Subtypes, Titration, Total antisera, Virology, Virus, Viruses antigenically, Younger virus.
Abstract
Abstract: We propose that changes in the antigenic region/s of influenza haemagglutinin can also cause changes in the binding site for host cells. If these changes have an overall deleterious effect on virus binding and hence on viral infectivity and reproduction one has a simple mechanism to explain the limited time span of influenza subtypes. Evidence is presented from the published results of other workers to support this hypothesis.
Url:
DOI: 10.1016/0306-9877(80)90014-6
Affiliations:
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Le document en format XML
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G." last="Whittaker">R. G. Whittaker</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>University of N.S.W., Kensington, N.S.W.</wicri:regionArea><wicri:noRegion>N.S.W.</wicri:noRegion></affiliation></author><author><name sortKey="Underwood, P A" sort="Underwood, P A" uniqKey="Underwood P" first="P. A." last="Underwood">P. A. Underwood</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>C.S.I.R.O. 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If these changes have an overall deleterious effect on virus binding and hence on viral infectivity and reproduction one has a simple mechanism to explain the limited time span of influenza subtypes. Evidence is presented from the published results of other workers to support this hypothesis.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Whittaker, R G" sort="Whittaker, R G" uniqKey="Whittaker R" first="R. G." last="Whittaker">R. G. Whittaker</name></noRegion><name sortKey="Underwood, P A" sort="Underwood, P A" uniqKey="Underwood P" first="P. A." last="Underwood">P. A. Underwood</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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